Colon Cancer Chemotherapy

Although there are different options available for treating colon cancer, for colon cancer treatment, chemotherapy is considered to be the best and most preferred option by the doctors for certain stages of colon cancer.  In this article, we will discuss about the  most effective treatment option  for colon cancer, the administration procedure of chemotherapy, availability of newest treatments, future developments in  colon cancer chemotherapy, etc. Colon cancer chemotherapy treatment is undertaken depending on the type and the stage of colon cancer.

Time of Administration

Essentially, colon cancer chemotherapy is administered in two integral parts at different stages of the disease. One is adjuvant chemotherapy, in which the attempt is taken to prevent the recurrence of the formation of cancerous cells following the surgical intervention carried out by the surgeon. This is a form of preventive chemotherapy. This is administered on those individuals who are at higher risk for recurrence of cancerous cells in the body. By administering adjuvant chemotherapy for six months, the risk is thus reduced.

On the other hand, the other part is administered on those patients who are already suffering from metastatic diseases. It is used in order to ensure a longer and healthier  life for them, while reducing the apparent symptoms caused by cancer.

In recent years, doctors, researchers and health practitioners are taking interest in newer agents which are more functional and beneficial in treating colon cancer to the extent where it might be surgically removed. With the benefit of these newer agents, the surgeons will be enabled with methods  to remove the cancer out of the liver and help the patient lead a l longer, healthier   and cancer free life.

Stage of Administration

Colon Cancer ChemotherapyNow the question is whether there is any set out norms that define the specific stage of administering chemotherapy treatment on a patient suffering from colon cancer. In general consideration, many oncologists  agree to the fact that adjuvant chemotherapy should be administered during Stage III, which implies the period when colon is already undergone the  resection process and by investigating it, the pathological tests confirm about the apparent evidences of metastatic diseases. Hence, at that phase, there is a possibility that the concerned patient will be benefited from chemotherapy after   the  surgery or resection.  In Stage IV disease, also referred to as metastatic disease, chemotherapy is administered in order to decrease the symptoms of disease.

Role of Chemotherapy in Disease Management

If you like to discuss about the disease management during perisurgical period, chemotherapy is one of the most useful options to convert the cancerous growth into an amenable growth for resection, exclusively in the rectum area. In combination with radiation therapy, chemotherapy helps in a better management of cancerous growth prior to surgical intervention. Apart from that, chemotherapy has been associated with sphincter salvaging surgery and it is found to be effective in dealing with colon cancer. In addition, down-sizing is possible with the administration of chemotherapy which certainly makes the surgical procedure less complicated. Patients undergoing chemotherapy treatment for  colon cancer receive a wealth of benefits including functional improvement, ability to preserve sphincter, with a minimal margin of risk with side effects of colon cancer chemotherapy.

Drugs or Agents used in Colon Cancer Chemotherapy

Chemotherapy drugs for colon cancer includes a variety of drugs namely 5-FU, oxaliplatin, irinotecan or camptosar, leucovorin, cetuximab etc. These drugs are administered in different combinations in the treatment for colon cancer.

In addition, there are other oral chemotherapy drugs such as Xeloda and UFT. Both of them are found to be effective in treating colon cancer.

Future Developments

The most important possibility about colon cancer is that more number of researches is being    carried out in order to understand the character of this malignancy in comparison with any other form of malignancies. In fact, the study area focusing on molecular genetics of colon cancer is indeed elaborating and fascinating. So, at present more and more researchers are taking interest in finding out the possible differences of molecular structure between colon cancer cells and normal cells and developing the agents that have an influence on them. Example may include, the agent responsible for inhibiting the receptor for epidermal growth factor. C225, a monoclonal antibody, is the target interest. These are the molecules that have some apparent influence over the function governing the interaction between epidermal growth factor and colon cancer.
In addition, there are few other agents that can cause inhibition to the ability of cancerous cells for developing new blood vessels. There are wide numbers of promising agents that function like an anti-angiogenesis agents. All of these agents are helpful in terms of clinical development including the sectors of medical oncology, surgical oncology, and radiation oncology.

Ongoing Clinical Trials

Those who are interested to take part in any sort of clinical trials for colon cancer chemotherapy can search for available options in the cancer centers scattered throughout the nation. National Cancer Institute and PDQ database can be a good of the source of information.