Metronomic Chemotherapy

Metronomic chemotherapy, where less is more

Cancer is one of the most threatening diseases plaguing human civilization and there are a number of treatments available for it nowadays. Metronomic Chemotherapy (Anti-Angiogenic Chemotherapy)One of the major methods of treating cancer is chemotherapy. It has some categories and is applied to the patients in varying amounts depending on the type of the disease. Chemotherapy is known for the adverse side effects it has on the body and this becomes a major concern for many people. However, there is a variant of this treatment called Metronomic chemotherapy which is a low dose chemotherapy treatment used for advanced stages of cancers.

Since metronomic chemotherapy applies significantly lower doses of drugs, it has lesser side effects on the human body. The researchers believe that this method will take cancer treatment to new heights. This method has proven to be effective with the patients who have developed resistance to the standard chemotherapy drugs. It works against the prevalent theory of chemotherapy by providing a steady stream of drugs applied in smaller doses. If this treatment does not work for the patients for cancer treatment then one can opt for the immunotherapy for cancer treatment.

On the contrary, traditional chemotherapy drugs works in the principle of applying the highest possible doses to eradicate the cancer afflicted cells. However, the drawback of the large doses is that they bring equally large adverse effects. This is where metronomic chemotherapy steps in. It attempts to diminish the harmful effects of the drugs while combating the malignant cells effectively.

Since, metronomic chemotherapy works by administering traditional chemotherapy drugs in small amounts, almost one tenth of the usual dose; it can be applied more often. Sometimes it may be possible to administer this form of chemotherapy on each day, something that is impossible with the traditional method. The patients who receive traditional chemotherapy are compelled to wait for weeks to allow their body to recover from the negative impacts of the drugs. For instance, often the blood count is reduced abysmally and a patient has to wait to let it gain normalcy. This interval period may also allow the tumor affected cells to mend and regenerate. This may prove to be counter productive for the patient.

The unique thing about metronomic chemotherapy is that it aims the endothelial cells more than the cancerous cells. The former are the cells that supply blood and the nutrients to the swelling tumor and allows it to grow. When the endothelial cells are destroyed, the blood supply is also cut.In that case, the tumor is contracted or the cancer cells can expire. Metronomic chemotherapy is also known as anti-antigenic chemotherapy. Cancer cells have the capability to metamorphose and hence develop resistance to conventional chemotherapy drugs. However, metronomic chemotherapy targets the endothelial cells that cannot evolve like the cancer cells.

As of now, the researchers are experimenting with metronomic chemotherapy in medical trials for treating a diverse range of cancers. These tests generally use an angiogenesis inhibitor with metronomic chemotherapy. According to some studies, they work better when used in alliance.